Phenotypes Associated with This Genotype

Genotype
MGI:5789775

• Allelic Composition: Tlr4^Lps-8Btlr/Tlr4⁺
• Genetic Background: C57BL/6J-Tlr4^Lps-8Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased macrophage cytokine production ( J:234241 )

• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

decreased interleukin-1 beta secretion ( J:234241 )

• some mice also exhibited attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1 in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

decreased tumor necrosis factor secretion ( J:234241 )

• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular

cellular necrosis ( J:234241 )

• mice showed resistance to LPS-induced macrophage necroptosis

increased cell death ( J:234241 )

• mice showed resistance to LPS-induced macrophage necroptosis

hematopoietic system

decreased macrophage cytokine production ( J:234241 )

• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)