Phenotypes Associated with This Genotype

Genotype
MGI:5789800

• Allelic Composition: Mir127^tm1.1Acfs/Mir127⁺
• Genetic Background: B6J.129-Mir127^tm1.1Acfs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:224145 )

• Background Sensitivity: the majority of mice on a C57BL/6J congenic background die within 1 day of birth when this allele is inherited paternally unlike mice on a mixed 129 and C57BL/6J background

• however, mice that survive more than 2 days survive into adulthood

embryo

abnormal placenta labyrinth morphology ( J:224145 )

• expanded volume and increased labyrinthine trophoblasts when this allele is inherited maternally

• reduced volume and decreased labyrinthine trophoblasts when this allele is inherited paternally

• however, mice exhibit normal junctional zone, decidual basalis and chorion regardless of allele inheritance

abnormal placenta fetal blood space morphology ( J:224145 )

• increased when this allele is inherited maternally

• decreased when this allele is inherited paternally

decreased placenta weight ( J:224145 )

• when this allele is inherited paternally

increased placenta weight ( J:224145 )

• when this allele is inherited maternally, mice exhibit enlarged placenta first apparent at E16.5 and at E18.5 compared with wild-type mice

abnormal placental transport ( J:224145 )

• increased theoretical diffusion capacity and specific diffusion capacity when this allele is inherited maternally

• decreased theoretical diffusion capacity and specific diffusion capacity when this allele is inherited paternally

growth/size/body

decreased birth body size ( J:224145 )

• when this allele is inherited paternally

• however, mice exhibit normal fetal weight and after birth growth when this allele is inherited maternally

postnatal growth retardation ( J:224145 )

• into adulthood when this allele is inherited paternally

fetal growth retardation ( J:224145 )

• at E16.5 when this allele is inherited paternally