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Phenotypes Associated with This Genotype
Genotype
MGI:5789965
Allelic
Composition		 Cgastm1a(EUCOMM)Hmgu/Cgastm1a(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cgastm1a(EUCOMM)Hmgu mutation (1 available); any Cgas mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interferon secretion ( J:234263 )
• production of type I interferon is reduced in macrophages following transfection with dsDNA (calf thymus DNA)
• production of type I interferon is reduced in MEFs following transfection with dsDNA (calf thymus DNA)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory