Phenotypes for Traf3ip3 MGI:5795854 MGI Mouse

immune system phenotype ( J:226431 )

N	• mice exhibit normal numbers of invariant NK T cells

abnormal T cell differentiation ( J:226431 )

• cell-intrinsic impairment in single positive thymocytes development

• in the thymus

• in the spleen

decreased T cell number ( J:226431 )

• reduced naive T cells

• however, the number of memory T cells is normal

decreased thymocyte number ( J:226431 )

• reduced frequencies of single positive CD4 or CD8 thymocytes

• however, DN1-4 stages are normal

• in the spleen

• in the spleen

• in the thymus and spleen

decreased thymocyte number ( J:226431 )

• reduced frequencies of single positive CD4 or CD8 thymocytes

• however, DN1-4 stages are normal

abnormal T cell differentiation ( J:226431 )

• cell-intrinsic impairment in single positive thymocytes development

• in the thymus

• in the spleen

decreased T cell number ( J:226431 )

• reduced naive T cells

• however, the number of memory T cells is normal

decreased thymocyte number ( J:226431 )

• reduced frequencies of single positive CD4 or CD8 thymocytes

• however, DN1-4 stages are normal

• in the spleen

• in the spleen

• in the thymus and spleen

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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