Phenotypes Associated with This Genotype

Genotype
MGI:5800450

• Allelic Composition: Krt2^{tm1a(KOMP)Wtsi}/Krt2^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
• Cell Lines: EPD0207_3_E04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

hypergranulosis ( J:214772 )

• upper suprabasal cells contain characteristic large keratohyalin granules of various shapes

abnormal epidermis suprabasal layer morphology ( J:214772 )

• decrease in the abundance of cytoplasmic keratin filament bundles in suprabasal cells of the ear skin

• the cytoplasm of suprabasal cells is rather electron-lucent with short, compact keratin filament bundles closely associated with desmosomes

• keratinocytes contain large poriferous keratin aggregates that are strongly positive for keratin 10 (K10) and often associated with desmosmes via filaments and regularly embedding mitochondria

epidermal hyperplasia ( J:214772 )

• increase in the number of epidermal cell layers in the ear skin