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Phenotypes Associated with This Genotype
Genotype
MGI:5803964
Allelic
Composition
Nr3c1tm2.1Ljm/Nr3c1tm2.1Ljm
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nr3c1tm2.1Ljm mutation (1 available); any Nr3c1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• with prior treatment with glucocorticoid stress hormone followed by middle cerebral artery occlusion

hematopoietic system
• prior to glucocorticoid stress hormone treatments fail to exhibit a reduction in numbers of infiltrating monocytes in infarcted hemisphere unlike in wild-type mice

homeostasis/metabolism
• with prior treatment with glucocorticoid stress hormone followed by middle cerebral artery occlusion
• prior treatment with glucocorticoid stress hormone fail to exhibit a reduction in numbers of infiltrating monocytes and IL6 protein levels in infarcted hemisphere after middle cerebral artery occlusion unlike in wild-type mice

immune system
• prior to glucocorticoid stress hormone treatments fail to exhibit a reduction in numbers of infiltrating monocytes in infarcted hemisphere unlike in wild-type mice
• in the ischemic cortex after middle cerebral artery occlusion
• in the hippocampus 12, but not 72, hours after kainic acid treatment
• prior treatment with glucocorticoid stress hormone fails to induce a decrease in IL6 levels in the ischemic cortex 24 h after middle cerebral artery occlusion

nervous system
• with prior treatment with glucocorticoid stress hormone followed by middle cerebral artery occlusion
• prior treatment with glucocorticoid stress hormone fail to exhibit a reduction in numbers of infiltrating monocytes and IL6 protein levels in infarcted hemisphere after middle cerebral artery occlusion unlike in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory