Phenotypes for Fus Mapt Ndor1 MGI:5824116 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi} Mapt^{tm3.1(FUS)Neas}/Mapt⁺ Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129 * C3H * C57BL/6 * C57BL/6N
Cell Lines	EPD0667_5_C04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fus^{tm1a(EUCOMM)Wtsi} mutation (0 available); any Fus mutation (40 available)
Fus^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Fus mutation (40 available)
Mapt^{tm3.1(FUS)Neas} mutation (0 available); any Mapt mutation (428 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:232167 )

• mice treated with tamoxifen postnatally show denervation in the tibialis anterior muscle where about 12% of neuromuscular junctions are denervated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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