Phenotypes for Shh Zic2 MGI:5827501 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shh^tm1Chg/Shh^tm1Chg Zic2^Ku/Zic2^Ku
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Zic2^Ku mutation (4 available); any Zic2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:138862 )

• embryos exhibit a heart defect

embryo

failure of initiation of embryo turning ( J:138862 )

• embryos fail to turn

decreased embryo size ( J:138862 )

growth/size/body

decreased embryo size ( J:138862 )

nervous system

abnormal forebrain morphology ( J:138862 )

• the forebrain is severely truncated at E9.5

• by E10.5, the forebrain forms a fluid-filled, cyst-like structure

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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