Phenotypes Associated with This Genotype

Genotype
MGI:5897108

• Allelic Composition: Sema3f^tm1.2Ddg/Sema3f^tm1.2Ddg; Sema3g^{tm1(KOMP)Vlcg}/Sema3g^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:226501 )

• synergistic increased lymphatic branching complexity

abnormal lymphatic vessel endothelial cell morphology ( J:226501 )

• increased numbers similar to in Sema3f^tm1.2Ddg homozygotes

• however, lymphatic endothelial cell progenitors exhibit normal migration

lymphatic vessel hyperplasia ( J:226501 )

• hyperplastic lymphatic vasculature in the back skin at E15.5

• however, defective back lymphatic network appears normal from E17.5 onward