Phenotypes Associated with This Genotype

Genotype
MGI:5897185

• Allelic Composition: Rgs9^{tm1.1(cre)Yql}/Rgs9⁺; Tg(CAG-Ppard*E411P)#Als/0
• Genetic Background: B6J.Cg-Rgs9^{tm1.1(cre)Yql} Tg(CAG-Ppard*E411P)#Als

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:233176 )

• mice develop motor abnormalities

• in the cage-ledge test, mice cannot easily dismount from the cage ledge

limb grasping ( J:233176 )

• mice exhibit a prominent clasping phenotype

impaired coordination ( J:233176 )

• mice exhibit worse latency-to-fall times on the accelerating rotarod

decreased grip strength ( J:233176 )

• reduction in combined mesh and grip-strength

nervous system

abnormal medium spiny neuron morphology ( J:233176 )

• reduction in parvalbumin-immunoreactive neurons, indicating a decrease in numbers of striatal neurons

neurodegeneration ( J:233176 )

• degeneration of striatal neurons

skeleton

kyphosis ( J:233176 )