Phenotypes Associated with This Genotype

Genotype
MGI:5897787

• Allelic Composition: Varc/Varc⁺
• Genetic Background: C3H/HeJ-Varc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired swimming ( J:241135 )

• one heterozgyote was tested and failed to orient in water

head tossing ( J:241135 )

• heterozygotes display head tossing and this phenotype is less evident when outcrossed to CAST/EiJ

circling ( J:241135 )

• Background Sensitivity: heterozygotes have a mild circling phenotype and this is less evident when outcrossed to CAST/EiJ

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:241135 )

• all mutants identified with head tossing and circling also have elevated ABR thresholds

increased susceptibility to otitis media ( J:241135 )

• some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media, and this is a secondary phenotype

immune system

increased susceptibility to otitis media ( J:241135 )

• some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media, and this is a secondary phenotype