Phenotypes Associated with This Genotype

Genotype
MGI:5897791

• Allelic Composition: Varc/Varc⁺
• Genetic Background: C3OuJ.C3-Varc/Kjn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head tossing ( J:241135 )

• heterozygotes display head tossing

circling ( J:241135 )

• Background Sensitivity: heterozygotes have a mild circling phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:241135 )

• all mutants identified with head tossing and circling also have elevated ABR thresholds

increased susceptibility to otitis media ( J:241135 )

• even in the presence of wild-type TLR4 some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media

immune system

increased susceptibility to otitis media ( J:241135 )

• even in the presence of wild-type TLR4 some, but not all, heterozygotes that display head tossing, circling, and elevated ABR thresholds also have otitis media