Phenotypes for Mcmdc2 Spo11 MGI:5898318 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Mcmdc2^{tm3b(EUCOMM)Hmgu}/Mcmdc2^{tm3b(EUCOMM)Hmgu} Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6N * CD-1
Cell Lines	HEPD0800_2_F07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcmdc2^{tm3b(EUCOMM)Hmgu} mutation (0 available); any Mcmdc2 mutation (32 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal synaptonemal complex ( J:236226 )

• significantly more non-homologous synaptonemal complex stretches in spermatocytes than in Mcmdc2 single knockout but similar to Spo11 single knockout

abnormal double-strand DNA break repair ( J:236226 )

• localized H2AX-rich chromatin domains (pseudo-sex bodies)

reproductive system

abnormal synaptonemal complex ( J:236226 )

• significantly more non-homologous synaptonemal complex stretches in spermatocytes than in Mcmdc2 single knockout but similar to Spo11 single knockout

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:236226 )

• localized H2AX-rich chromatin domains (pseudo-sex bodies)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24