Phenotypes Associated with This Genotype

Genotype
MGI:5902125

• Allelic Composition: Braf^tm1Mmcm/Braf⁺; Tg(Tyr-cre/ERT2)13Bos/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal melanocyte morphology ( J:151023 )

• pigmented lesions in 4-HT treated mice are frequently located at the dermal-epidermal junction with extension into the dermis, indicating melanocytic nevi

• other melanocytic proliferations form in the dermis with no junctional component in 4-HT treated mice

integument

skin lesions ( J:151023 )

• mice treated with 4-hydroxytamoxifen (4-HT) either topically or systemically develop highly pigmented lesions that are detected by 21-28 days after 4-HT administration; these are small papular pigmented lesions that are not malignant

• topical administration of high concentrations of 4-HT occasionally results in periocular lesions on the face and on the glabrous skin of the paws