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Phenotypes Associated with This Genotype
Genotype
MGI:5903129
Allelic
Composition		 Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5tm1.1Namt mutation (0 available); any Cxcr5 mutation (28 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:241561 )
• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice
• however, accumulation of prions in medial lymph nodes is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory