Phenotypes Associated with This Genotype

Genotype
MGI:5904181

• Allelic Composition: Igf1r^tm1Jcbr/Igf1r^tm1Jcbr; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:241923 )

• mice are significantly overweight after puberty

homeostasis/metabolism

abnormal response to injury ( J:241923 )

• mice show a delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

• mice show increased proliferation of bronchiolar epithelial cells during repair of the epithelium after naphthalene treatment to induce damage and club cell ablation

respiratory system

abnormal bronchiole epithelium morphology ( J:241923 )

• smaller epithelial cell size in terminal bronchioles

• lower proportion of Scgb1a1+ club cells

• distal bronchiolar epithelium shows morphological changes including lower cell density, flatter cells with elongated nuclei and frequent interruptions of normal columnar organization

• however, no gross morphological alterations are seen in AEC2 cells or in the surrounding alveolar parenchyma

• proliferation of airway club cells is enhanced in terminal bronchial epithelium