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Phenotypes Associated with This Genotype
Genotype
MGI:5904345
Allelic
Composition		 E2f4tm2.1Lees/E2f4tm2.1Lees
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (1027 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory motile cilium morphology ( J:241925 )
• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium
• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium
• however, primary cilia formation occurs

cellular
abnormal respiratory motile cilium morphology ( J:241925 )
• mice treated with 4-hydroxytamoxifen show disruption of multiciliogenesis in lung epithelium
• 4-hydroxytamoxifen treated mice are unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium
• however, primary cilia formation occurs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory