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Phenotypes Associated with This Genotype
Genotype
MGI:5904347
Allelic
Composition		 E2f4tm2.1Lees/E2f4tm2.1Lees
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory motile cilium morphology ( J:241925 )
• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium
• however, primary cilia formation occurs

cellular
abnormal respiratory motile cilium morphology ( J:241925 )
• mice are unable to form multiciliated cells and unable to form deuterosomes and Pcm1-containing aggregates in lung epithelium
• however, primary cilia formation occurs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory