Phenotypes Associated with This Genotype

Genotype
MGI:5907356

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mlip)Dzw}/Gt(ROSA)26Sor⁺; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:227485 )

N • no cardiac phenotype under baseline conditions

decreased response of heart to induced stress ( J:227485 )

• at 4 weeks after transverse aortic constriction (TAC) cardiac hypertrophy is suppressed and cardiac function is preserved compared to similarly treated wild-type controls

• cardiac function is preserved and no signs of left ventricular dilation are seen after 10 weeks of TAC unlike in controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:227485 )

• at 4 weeks after transverse aortic constriction (TAC) cardiac hypertrophy is suppressed and cardiac function is preserved compared to similarly treated wild-type controls

• cardiac function is preserved and no signs of left ventricular dilation are seen after 10 weeks of TAC unlike in controls