Phenotypes for Pln Tnnt2 MGI:5910773 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pln^tm1Egk/Pln^tm1Egk Tnnt2^tm2.1Feah/Tnnt2⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pln^tm1Egk mutation (7 available); any Pln mutation (16 available)
Tnnt2^tm2.1Feah mutation (0 available); any Tnnt2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart left ventricle ( J:243725 )

• mice exhibit left ventricular dilatation

dilated cardiomyopathy ( J:243725 )

• dilated cardiomyopathy is similar to that seen in single Tnnt2 heterozygotes

decreased cardiac muscle contractility ( J:243725 )

• mice exhibit decreased fractional shortening

muscle

dilated cardiomyopathy ( J:243725 )

• dilated cardiomyopathy is similar to that seen in single Tnnt2 heterozygotes

decreased cardiac muscle contractility ( J:243725 )

• mice exhibit decreased fractional shortening

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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