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Phenotypes Associated with This Genotype
Genotype
MGI:5912243
Allelic
Composition		 Ace2tm1Pngr/Y
Genetic
Background		 B6.129P2-Ace2tm1Pngr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:124548 )
N
• heart angiotensin II levels are not elevated and superoxide production is normal indicating lack of oxidative stress in aged mice

immune system
decreased susceptibility to Coronaviridae infection ( J:286299 )
• mice show decreased susceptibility to intranasal infection with severe acute respiratory syndrome coronavirus (SARS-CoV; Beijing strain, PUMC01 isolate) , showing lower levels of infectious virus in the lungs, reduced copy numbers of the SARS-CoV Spike RNA, and reduced pathologic alterations in lungs compared to infected wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory