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Phenotypes Associated with This Genotype
Genotype
MGI:6107905
Allelic
Composition		 Bag3tm1c(EUCOMM)Hmgu/Bag3tm1c(EUCOMM)Hmgu
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Tg(Myhca-cre)1Abel/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N
Cell Lines HEPD0556_7_B06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3tm1c(EUCOMM)Hmgu mutation (2 available); any Bag3 mutation (31 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myhca-cre)1Abel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired autophagy ( J:246352 )
• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

homeostasis/metabolism
impaired autophagy ( J:246352 )
• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory