Phenotypes Associated with This Genotype

Genotype
MGI:6113383

• Allelic Composition: Nfkb1^M3Btlr/Nfkb1^M3Btlr
• Genetic Background: C57BL/6J-Nfkb1^M3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:254821 )

• induced by DSS

increased central memory CD8 positive, alpha-beta T cell number ( J:254821 )

abnormal humoral immune response ( J:254821 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgE level ( J:254821 )

decreased IgG level ( J:254821 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

digestive/alimentary system

increased susceptibility to induced colitis ( J:254821 )

• induced by DSS

hematopoietic system

increased central memory CD8 positive, alpha-beta T cell number ( J:254821 )

decreased IgE level ( J:254821 )

decreased IgG level ( J:254821 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)