Phenotypes Associated with This Genotype

Genotype
MGI:6113389

• Allelic Composition: Nfkb1^m2Btlr/Nfkb1^m2Btlr
• Genetic Background: C57BL/6J-Nfkb1^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254822 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254822 )

abnormal humoral immune response ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgE level ( J:254822 )

decreased IgG level ( J:254822 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization

hematopoietic system

decreased central memory CD4-positive, alpha-beta T cell number ( J:254822 )

decreased effector memory CD4-positive, alpha-beta T cell number ( J:254822 )

increased central memory CD8 positive, alpha-beta T cell number ( J:254822 )

decreased CD8-positive, naive alpha-beta T cell number ( J:254822 )

decreased IgE level ( J:254822 )

decreased IgG level ( J:254822 )

• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:254822 )

• decreased TNP-specific IgM to TNP-Ficoll immunization