Phenotypes Associated with This Genotype

Genotype
MGI:6116890

• Allelic Composition: Foxg1^tm1(cre)Skm/Foxg1⁺; Frs2^tm1Fwan/Frs2^tm1Fwan; Frs3^tm1Jheb/Frs3^tm1Jheb
• Genetic Background: involves: 129 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:242687 )

N • differentiating field of cortical GABAergic interneurons at E13.5 according to Shh and Lhx6 labeling

abnormal cortical ventricular zone morphology ( J:242687 )

• reduced size of Dlx2-labeled region at E13.5

telencephalon hypoplasia ( J:242687 )

• reduction in size across A/P (-24%) and D/V (-16%) axes at E13.5

abnormal embryonic/fetal subventricular zone morphology ( J:242687 )

• reduced cell division at E13.5 according to mitotic marker p-HH3 immunoreactivity

abnormal lateral ganglionic eminence morphology ( J:242687 )

• reduction in subset of dopaminergic olfactory interneuron progenitors in dorsal LGE at E13.5 according to Pax6 labeling

abnormal medial ganglionic eminence morphology ( J:242687 )

• reduced size of Nkx2-1-labeled region in MGE and pre-optic area at E13.5

• size of Nkx2-1-labeled region in MGE and pre-optic area at E10.5

• reduced size of Lhx8-labeled differentiating domain at E13.5

craniofacial

frontonasal prominence hypoplasia ( J:242687 )

• at E10.5 and E13.5

vision/eye

microphthalmia ( J:242687 )

• at E13.5

cellular

cellular phenotype ( J:242687 )

N • cell survival in telencephalon at E10.5 and E13.5