Phenotypes Associated with This Genotype

Genotype
MGI:6149725

• Allelic Composition: Trim25^tm1Mura/Trim25⁺; Usp15^L749R/Usp15⁺
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )

• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)