About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6154210
Allelic
Composition		 Sox10tm1Weg/Sox10tm1Weg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent Schwann cells ( J:260791 )
• spinal nerves of E18.5 mutants are devoid of Schwann cells
abnormal oligodendrocyte physiology ( J:260791 )
• the number of cells that have already started to express myelin genes such as Mbp and Plp1 are almost absent in the spinal cord at E18.5, indicating impaired differentiation of oligodendrocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory