Phenotypes Associated with This Genotype

Genotype
MGI:6154211

• Allelic Composition: Sox10^tm1Weg/Sox10⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

megacolon ( J:260791 )

• fewer than 5% of mice succumb to a megacolon around time of weaning

nervous system

abnormal oligodendrocyte physiology ( J:260791 )

• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days

• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

integument

belly spot ( J:260791 )

• white belly spot is fully penetrant from second generation backcross to C3H and onwards

pigmentation

belly spot ( J:260791 )

• white belly spot is fully penetrant from second generation backcross to C3H and onwards