Phenotypes Associated with This Genotype

Genotype
MGI:6157077

• Allelic Composition: Fbxw7^tm1.1Iken/Fbxw7⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:258194 )

• no living newborns are obtained, however normal ratios of E18.5 embryos are seen, indicating that mutants die around birth

respiratory system

thick pulmonary interalveolar septum ( J:258194 )

• alveolar septa are thickened at E18.5

abnormal respiratory system physiology ( J:258194 )

• increase in the number of proliferating cells (Ki67+) in the lung

respiratory failure ( J:258194 )

• aerated lung areas are small and alveolar septa are thickened at E18.5, suggesting respiratory failure as cause of perinatal lethality

craniofacial

cleft palate ( J:258194 )

• 1.3% of mutants exhibit cleft palate

digestive/alimentary system

cleft palate ( J:258194 )

• 1.3% of mutants exhibit cleft palate

growth/size/body

cleft palate ( J:258194 )

• 1.3% of mutants exhibit cleft palate

vision/eye

eyelids open at birth ( J:258194 )

• 17% of mutants exhibit eyes open at birth