Phenotypes Associated with This Genotype

Genotype
MGI:6158521

• Allelic Composition: Specc1l^{Gt(DTM096)Byg}/Specc1l^{Gt(DTM096)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased apoptosis ( J:250140 )

• in E9.5 embryos

abnormal cranial neural crest cell migration ( J:250140 )

• fail to migrate, remaining in neural folds at E10.5

abnormal neural crest cell delamination ( J:250140 )

• cranial neural crest cells (CNCCs) remain in neural folds at E10.5

embryo

abnormal cranial neural crest cell migration ( J:250140 )

• fail to migrate, remaining in neural folds at E10.5

abnormal neural crest cell delamination ( J:250140 )

• cranial neural crest cells (CNCCs) remain in neural folds at E10.5

abnormal neural tube closure ( J:250140 )

• mostly failure of anterior (rostral) side, sometimes posterior (caudal)

mortality/aging

embryonic lethality, complete penetrance ( J:250140 )

• most embryos die by E10.5

• no mice are born

nervous system

abnormal neural tube closure ( J:250140 )

• mostly failure of anterior (rostral) side, sometimes posterior (caudal)