Phenotypes Associated with This Genotype

Genotype
MGI:6160728

• Allelic Composition: Pgap6^tm1Osb/Pgap6^tm1Osb
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal anterior-posterior axis formation in Pgap6^tm1Osb/Pgap6^tm1Osb embryos

mortality/aging

embryonic lethality, incomplete penetrance ( J:258200 )

• all homozygotes except one are embryonic lethal; only 1 out of 244 pups born from heterozygous crosses is a homozygote

• homozygotes exhibiting anterior-posterior axis defects at E6.7 undergo regression at E8.0; those that pass the stage of anterior-posterior axis formation also die before E9.0

embryo

abnormal rostral-caudal axis patterning ( J:258200 )

• at E6.7, only 3 of 13 of homozygotes show abnormal anterior-posterior axis formation; Cerl (cerberus 1, DAN family BMP antagonist) is abnormally expressed in the distal visceral endoderm while Brachyury is broadly localized in a proximal area near the embryonic/extraembryonic constriction

embryonic growth arrest ( J:258200 )

• most homozygotes exhibit cessation of embryonic growth at E9.0