Phenotypes Associated with This Genotype

Genotype
MGI:6192036

• Allelic Composition: Tg(Myh6-Mir30c-1)BEec/0
• Genetic Background: involves: C57BL/6JOlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:216095 )

• 50% mortality at 21 weeks of age

cardiovascular system

increased heart right atrium size ( J:216095 )

thin ventricular wall ( J:216095 )

• extensive thinning of the ventricular walls, especially in the right ventricle

decreased heart right ventricle wall thickness ( J:216095 )

cardiac interstitial fibrosis ( J:216095 )

• stretches of interstitial fibrosis in the ventricles and atria at 6 weeks of age

dilated cardiomyopathy ( J:216095 )

• mice develop a severely dilated cardiomyopathy after 6 weeks of age

decreased cardiac muscle contractility ( J:216095 )

• cardiac function is decreased, with a reduction of ejection fraction from 70% to 54% and a 30% decrease in fractional shortening at 6 weeks of age

abnormal heart echocardiography feature ( J:216095 )

• echocardiography at 6 weeks of age shows increased left ventricular internal diameter in systole and diastole

cellular

cardiac interstitial fibrosis ( J:216095 )

• stretches of interstitial fibrosis in the ventricles and atria at 6 weeks of age

abnormal mitochondrial physiology ( J:216095 )

• gene expression analysis indicates disturbed mitochondrial function and downregulation of mitochondrial oxidative phosphorylation complexes III and IV at the protein level, suggesting that cardiomyocytes have impaired oxidative capacity

muscle

dilated cardiomyopathy ( J:216095 )

• mice develop a severely dilated cardiomyopathy after 6 weeks of age

decreased cardiac muscle contractility ( J:216095 )

• cardiac function is decreased, with a reduction of ejection fraction from 70% to 54% and a 30% decrease in fractional shortening at 6 weeks of age