Phenotypes Associated with This Genotype

Genotype
MGI:6194662

• Allelic Composition: Lsm3^em1Caox/Lsm3^em1Caox
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

immune system

increased circulating interferon-alpha level ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

increased circulating interferon-beta level ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

• following infection with influenza virus strain A/Puerto Rico/8/1981

increased circulating interleukin-6 level ( J:262834 )

• following infection with influenza virus strain A/Puerto Rico/8/1981

decreased susceptibility to Riboviria infection ( J:262834 )

• following infection of vesicular stomatitis virus with a moderate dose, mice exhibit increased serum alpha and beta interferon, reduced viral burden, reduced severity of pulmonary inflammation, and decreased mortality compared with wild-type mice

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

decreased susceptibility to Orthomyxoviridae infection ( J:262834 )

• mice infected with influenza virus strain A/Puerto Rico/8/1981 exhibit higher levels of FBN-beta and IL6 compared with wild-type mice

homeostasis/metabolism

increased circulating interferon-alpha level ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

increased circulating interferon-beta level ( J:262834 )

• following infection of vesicular stomatitis virus with a high dose

• following infection with influenza virus strain A/Puerto Rico/8/1981

increased circulating interleukin-6 level ( J:262834 )

• following infection with influenza virus strain A/Puerto Rico/8/1981