Phenotypes Associated with This Genotype

Genotype
MGI:6196876

• Allelic Composition: Rubcn^em1Dgre/Rubcn^em1Dgre
• Genetic Background: C57BL/6-Rubcn^em1Dgre

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:261225 )

N • normal numbers of B, T and NK cells in spleens and lymph nodes and normal T cell subsets in thymi

abnormal macrophage physiology ( J:261225 )

• reduced recruitment of Becn1, Uvrag, Pick3c3 (VPS34), Map1lc3 (LC3-II) and Atg7 to LAP (LC3-associated phagocytosis)-engaged phagosomes

• no recruitment of Atg5-12 and Atg16l to LAP (LC3-associated phagocytosis)-engaged phagosomes

• lack of phosphatidylinositol 3-phosphate generation by Pick3c3 (VPS34) associated with LAP (LC3-associated phagocytosis)-engaged phagosomes

• failure to produce ROS (reactive oxygen species) upon zymosan stimulation

• lack of phosphorylated Ncf4 (p-p40PHOX) in LAP (LC3-associated phagocytosis)-engaged phagosomes

• levels of Cyba (p22PHOX) in LAP (LC3-associated phagocytosis)-engaged phagosomes

immune system

immune system phenotype ( J:261225 )

N • normal numbers of B, T and NK cells in spleens and lymph nodes and normal T cell subsets in thymi

abnormal macrophage physiology ( J:261225 )

• reduced recruitment of Becn1, Uvrag, Pick3c3 (VPS34), Map1lc3 (LC3-II) and Atg7 to LAP (LC3-associated phagocytosis)-engaged phagosomes

• no recruitment of Atg5-12 and Atg16l to LAP (LC3-associated phagocytosis)-engaged phagosomes

• lack of phosphatidylinositol 3-phosphate generation by Pick3c3 (VPS34) associated with LAP (LC3-associated phagocytosis)-engaged phagosomes

• failure to produce ROS (reactive oxygen species) upon zymosan stimulation

• lack of phosphorylated Ncf4 (p-p40PHOX) in LAP (LC3-associated phagocytosis)-engaged phagosomes

• levels of Cyba (p22PHOX) in LAP (LC3-associated phagocytosis)-engaged phagosomes

mortality/aging

mortality/aging ( J:261225 )

N • mice are born at expected Mendelian ratios