About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6196878
Allelic
Composition		 Rubcnem1Dgre/Rubcnem1Dgre
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * C57BL/6NCrlj * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rubcnem1Dgre mutation (1 available); any Rubcn mutation (39 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage morphology ( J:261225 )
• increased numbers of LC3 (Map1lc3) puncta
abnormal macrophage physiology ( J:261225 )
• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome
• phagocytosis

immune system
abnormal macrophage morphology ( J:261225 )
• increased numbers of LC3 (Map1lc3) puncta
abnormal macrophage physiology ( J:261225 )
• unable to translocate LC3 (Map1lc3) to LAP (LC3-associated phagocytosis)-engaged phagosome
• phagocytosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory