Phenotypes for Ptpn6 MGI:6199042 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ptpn6^m4Btlr/Ptpn6^m4Btlr
Genetic Background	C57BL/6J-Ptpn6^m4Btlr

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6^m4Btlr mutation (0 available); any Ptpn6 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B-1 B cell number ( J:264807 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:264807 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:264807 )

increased CD8-positive, alpha-beta memory T cell number ( J:264807 )

increased central memory CD8 positive, alpha-beta T cell number ( J:264807 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:264807 )

decreased CD8-positive, naive alpha-beta T cell number ( J:264807 )

hematopoietic system

increased B-1 B cell number ( J:264807 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:264807 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:264807 )

increased CD8-positive, alpha-beta memory T cell number ( J:264807 )

increased central memory CD8 positive, alpha-beta T cell number ( J:264807 )

increased effector memory CD8-positive, alpha-beta T cell number ( J:264807 )

decreased CD8-positive, naive alpha-beta T cell number ( J:264807 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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