Phenotypes Associated with This Genotype

Genotype
MGI:6200381

• Allelic Composition: Pi4ka^m1Btlr/Pi4ka^m1Btlr
• Genetic Background: C57BL/6J-Pi4ka^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased macrophage apoptosis ( J:265261 )

• decrease in LPS-induced necroptosis

increased interleukin-1 beta secretion ( J:265261 )

• increased inflammatory responses related to increased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment

decreased tumor necrosis factor secretion ( J:265261 )

• reduced TNFalpha secretion in response to the TLR1/2 ligand PAM3CSK4

cellular

decreased macrophage apoptosis ( J:265261 )

• decrease in LPS-induced necroptosis

increased cell death ( J:265261 )

• reduced MTT values of peritoneal exudate cells

hematopoietic system

decreased macrophage apoptosis ( J:265261 )

• decrease in LPS-induced necroptosis