Phenotypes Associated with This Genotype

Genotype
MGI:6201524

• Allelic Composition: Fbxo43^tm1.2Kald/Fbxo43^tm1.2Kald
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:251984 )

♀ • with a germinal vesicle-like structure with chromatin (likely decondensed)

azoospermia ( J:251984 )

♂ • absence of spermatid at p63 and sperm in epididymis at P120

abnormal female meiosis ( J:251984 )

♀ • arrested in metaphase meiosis II

parthenogenesis ( J:251984 )

♀ • parthenogenetic divisions in oocytes of 2 of 11 mice

arrest of male meiosis ( J:251984 )

♂ • in prophase in meiosis I

♂ • however, meiotic recombination and resolution of double-strand breaks is normal

increased male germ cell apoptosis ( J:251984 )

♂ • at stage XII (pachytene/diplotene)

small testis ( J:251984 )

♂

decreased testis weight ( J:251984 )

♂

female infertility ( J:251984 )

♀

male infertility ( J:251984 )

♂

neoplasm

neoplasm ( J:251984 )

♀N • despite parthenogenetic oocyte divisions, female mice do not develop ovarian cancer

endocrine/exocrine glands

small testis ( J:251984 )

♂

decreased testis weight ( J:251984 )

♂

cellular

abnormal oocyte morphology ( J:251984 )

♀ • with a germinal vesicle-like structure with chromatin (likely decondensed)

azoospermia ( J:251984 )

♂ • absence of spermatid at p63 and sperm in epididymis at P120

abnormal female meiosis ( J:251984 )

♀ • arrested in metaphase meiosis II

parthenogenesis ( J:251984 )

♀ • parthenogenetic divisions in oocytes of 2 of 11 mice

arrest of male meiosis ( J:251984 )

♂ • in prophase in meiosis I

♂ • however, meiotic recombination and resolution of double-strand breaks is normal

increased male germ cell apoptosis ( J:251984 )

♂ • at stage XII (pachytene/diplotene)