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Phenotypes Associated with This Genotype
Genotype
MGI:6201527
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1027 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:251984 )
• within 4 to 5 days after treatment with tamoxifen at around age P21

reproductive system
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21

cellular
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory