Phenotypes Associated with This Genotype

Genotype
MGI:6266861

• Allelic Composition: Tg(Tyr-HRAS*G12V)#Acc/0
• Genetic Background: involves: C3H/HeN * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:90877 )

• soon after birth, mice exhibit a light grayish brown (muted agouti) coat color

pigment incontinence ( J:90877 )

• mice show extensive deposition of melanin within the reticular dermis and upper dermal region

abnormal extracutaneous pigmentation ( J:90877 )

abnormal choroid pigmentation ( J:90877 )

• at 10-16 weeks of age, uveal tissue is thickened and heavily pigmented

abnormal choroid melanocyte morphology ( J:90877 )

• heavily pigmented benign melanocytic lesions of the choroid are observed

abnormal otic pigmentation ( J:90877 )

• at 10-16 weeks of age, pigmentation is observed in the inner ear

increased melanocyte number ( J:90877 )

• mice show increased numbers of melanocytes both in hair bulbs and in the dermal layer of the skin

hyperpigmentation ( J:90877 )

• the skin of the snout, ears, neck region, feet, and tail is darkly pigmented by 1-2 weeks of age, unlike in control littermates

• at 10-16 weeks of age, pigmentation is noted in the choroid plexus of the fourth ventricle, dura mater (meninges), choroid of the eye, periocular fascia, and inner ear

• the cervical lymph nodes and Kupffer cells of the liver also contain melanin, which appears to be contained in phagocytic cells

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

increased foot pigmentation ( J:90877 )

• the hind feet are darkly pigmented, unlike in control littermates

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

increased skin pigmentation ( J:90877 )

• when body hair is shaved, skin shows a dark bluish gray color in areas normally covered with hair, unlike in control littermates where skin is pink

• at 10-16 weeks of age, melanosis is noted in the dermal and epidermal layers of the skin of the neck, nose, tail, foot and external ear canal

nervous system

abnormal brain meninges morphology ( J:90877 )

• at 10-16 weeks of age, pigmentation is noted in the dura mater (meninges)

• some hypercellularity is noted around the meningeal membranes

integument

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

diluted coat color ( J:90877 )

• soon after birth, mice exhibit a light grayish brown (muted agouti) coat color

skin lesions ( J:90877 )

• at 3-5 weeks of age, mice exhibit nevi on the dorsal sides of the body

• at 10-16 weeks of age, lesions similar to blue nevi are frequently observed

increased foot pigmentation ( J:90877 )

• the hind feet are darkly pigmented, unlike in control littermates

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

increased skin pigmentation ( J:90877 )

• when body hair is shaved, skin shows a dark bluish gray color in areas normally covered with hair, unlike in control littermates where skin is pink

• at 10-16 weeks of age, melanosis is noted in the dermal and epidermal layers of the skin of the neck, nose, tail, foot and external ear canal

pigment incontinence ( J:90877 )

• mice show extensive deposition of melanin within the reticular dermis and upper dermal region

growth/size/body

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

decreased body size ( J:90877 )

• mice are significantly smaller than control littermates

hearing/vestibular/ear

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

abnormal inner ear morphology ( J:90877 )

• mice exhibit abnormal inner ear tissue morphology, with obliteration of the bony structure

abnormal cochlea morphology ( J:90877 )

• the cochlear space contains an abnormal tissue mass composed of poorly differentiated spindle-to stellate cells in a loose myxomatous-like arrangement; many pigment-producing cells are found within the tissue mass

abnormal middle ear morphology ( J:90877 )

• mice exhibit abnormal middle ear tissue morphology

deafness ( J:90877 )

• mice appear to be deaf

behavior/neurological

circling ( J:90877 )

• when mice begin walking they often walk or run in circles

bidirectional circling ( J:90877 )

unidirectional circling ( J:90877 )

• although twirling is observed in both directions, each mouse circles primarily in one direction

vision/eye

abnormal choroid pigmentation ( J:90877 )

• at 10-16 weeks of age, uveal tissue is thickened and heavily pigmented

abnormal choroid melanocyte morphology ( J:90877 )

• heavily pigmented benign melanocytic lesions of the choroid are observed

abnormal eye anterior chamber morphology ( J:90877 )

• at 10-16 weeks of age, melanocytic lesions of the anterior chamber are observed

cataract ( J:90877 )

• at 10-16 weeks of age, mice exhibit cataracts

abnormal eyelid morphology ( J:90877 )

• at 10-16 weeks of age, eyelids appear enlarged and contain melanin

narrow eye opening ( J:90877 )

• mice never fully open their eyelids

limbs/digits/tail

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

craniofacial

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

neoplasm

neoplasm ( J:90877 )

N • no spontaneous cutaneous melanomas are observed up to 48 weeks of age