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Phenotypes Associated with This Genotype
Genotype
MGI:6267349
Allelic
Composition		 Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (37 available)
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:266848 )
• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell
decreased bone marrow cell number ( J:266848 )
• modest reduction in pIpC-treated mice
decreased hematopoietic stem cell number ( J:266848 )
• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory