Phenotypes Associated with This Genotype

Genotype
MGI:6274238

• Allelic Composition: Katnal2^m1Anu/Katnal2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0656_4_A03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spermiation and spermatid defects in Katnal2^m1Anu/Katnal2^{tm1a(EUCOMM)Wtsi} mice

reproductive system

abnormal elongated spermatid morphology ( J:250115 )

♂ • elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology

multinucleated giant male germ cells ( J:250115 )

♂ • multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal seminiferous tubule epithelium morphology ( J:250115 )

♂ • multinucleated symplasts are frequently observed in the seminiferous epithelium

abnormal spermiation ( J:250115 )

♂ • total epididymal sperm content is reduced by 94.5% relative to wild-type controls; however, testis weight and daily sperm output in the testes are normal, indicating a massive failure of spermiation

♂ • retained elongated spermatids are often observed in stage IX seminiferous tubules, unlike in wild-type controls

male infertility ( J:250115 )

♂ • males are sterile and exhibit an apparently identical male fertility phenotype to that observed in Katnal2^m1Anu homozygotes

cellular

abnormal elongated spermatid morphology ( J:250115 )

♂ • elongating spermatids frequently exhibit abnormal nuclear (club shaped) morphology

multinucleated giant male germ cells ( J:250115 )

♂ • multinucleated symplasts are frequently observed in the seminiferous epithelium

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:250115 )

♂ • multinucleated symplasts are frequently observed in the seminiferous epithelium