Phenotypes Associated with This Genotype

Genotype
MGI:6278109

• Allelic Composition: Chchd4^{Gt(IST11943B12)Tigm}/Chchd4⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:250035 )

♀ • when fed a Western style high-fat diet starting from 4 weeks of age, heterozygotes exhibit a significantly reduced weight gain compared to age- and sex-matched wild-type controls

♀ • however, no differences in weight gain are observed on a normal chow diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:250035 )

♀ • when fed a Western style high-fat diet starting from 4 weeks of age, heterozygotes exhibit a significantly reduced weight gain compared to age- and sex-matched wild-type controls

♀ • however, no differences in weight gain are observed on a normal chow diet

mortality/aging

mortality/aging ( J:250035 )

N • heterozygotes have a life expectancy of at least 1.5 years with no apparent pathology

cellular

cellular phenotype ( J:250035 )

N • heterozygotes show no major respiratory chain defects relative to wild-type controls