Phenotypes Associated with This Genotype

Genotype
MGI:6279162

• Allelic Composition: Cpne6^tm1.1Rueg/Cpne6^tm1.1Rueg
• Genetic Background: B6.Cg-Cpne6^tm1.1Rueg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:239922 )

N • adult male homozygotes exhibit normal open field behavior and foot-shock sensitivity

impaired contextual conditioning behavior ( J:239922 )

• in a fear-conditioning paradigm, adult male homozygotes exhibit a significant deficit in learning and context-dependent memory relative to wild-type controls

• however, no deficits are observed in amygdala-dependent cued memory