Analysis Tools
mortality/aging
|
• only 5 of 37 pups born survive past postnatal day 2
|
|
• fewer than 15% of the born pups survive past postnatal day 2
• however, pups that survive the neonatal period are healthy, fertile and indistinguishable from wild-type controls
|
|
• mice are born at a significantly lower than expected frequency from heterozygous mating pairs
|
immune system
| N |
• surviving mice show no differences in the development, maturation and differentiation of B-lymphocytes into antibody secreting cells or in immunoglobulin class-switch recombination relative to wild-type controls
|
