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Phenotypes Associated with This Genotype
Genotype
MGI:6283530
Allelic
Composition		 Tcf12m4Btlr/Tcf12m4Btlr
Genetic
Background		 C57BL/6J-Tcf12m4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12m4Btlr mutation (0 available); any Tcf12 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell morphology ( J:271972 )
• reduced B to T cell ratios in the peripheral blood
abnormal T cell morphology ( J:271972 )
• reduced CD4 to CD8 T cell ratios in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:271972 )
• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:271972 )
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
abnormal B cell morphology ( J:271972 )
• reduced B to T cell ratios in the peripheral blood
abnormal T cell morphology ( J:271972 )
• reduced CD4 to CD8 T cell ratios in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:271972 )
• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:271972 )
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory