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Phenotypes Associated with This Genotype
Genotype
MGI:6287398
Allelic
Composition
anx/anx
Tg(TYRO3)1Sapc/?
Tyro3m1/Tyro3m1
Genetic
Background
involves: C3HeB/FeJLe * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(TYRO3)1Sapc mutation (0 available)
Tyro3m1 mutation (4 available); any Tyro3 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• relative to anx homozygotes lacking the TYRO3 human wildtype transgene, these mice show a partial rescue of the anorexia phenotype with the body weight at 21 days of age 92.8% increased on average

mortality/aging
• wildtype human TYRO3 partially rescues the anx homozygous phenotype, with anx homozygotes still dying prematurely, but surviving past 35 days of age and showing no or only mild behavioural phentoypes of headweaving, ataxia, or tremors


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory