Phenotypes Associated with This Genotype

Genotype
MGI:6294492

• Allelic Composition: Tg(Myh6*/tetO-Hspb8*K141N)#Atsa/0; Tg(Myh6-tTA)55Rbns/0
• Genetic Background: involves: C57BL/6CrSlc * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:197853 )

• intracellular aggregates containing the mutant protein and amyloid oligomer are seen in the hearts of 6 months old mice

cardiac hypertrophy ( J:197853 )

• mice exhibit cardiac hypertrophy, with increased heart weight/body weight ratios at 6 months of age

cardiac fibrosis ( J:197853 )

• hearts exhibit mild apical cardiac fibrosis at 6 months of age

decreased cardiac muscle contractility ( J:197853 )

• fractional shortening and ejection fraction are slightly reduced in 6 month old mice, indicating slightly reduced cardiac function

cardiomyopathy ( J:197853 )

• mice develop cardiac disease by 6 months of age

cellular

abnormal oxidative phosphorylation ( J:197853 )

• oxidative phosphorylation ratio, respiratory control index, and oxygen consumption in state 3 are decreased in heart mitochondria of 6 month old mice

homeostasis/metabolism

amyloid beta deposits ( J:197853 )

• intracellular aggregates containing amyloid oligomer are seen in hearts of 6 month old mice

muscle

decreased cardiac muscle contractility ( J:197853 )

• fractional shortening and ejection fraction are slightly reduced in 6 month old mice, indicating slightly reduced cardiac function

cardiomyopathy ( J:197853 )

• mice develop cardiac disease by 6 months of age

nervous system

amyloid beta deposits ( J:197853 )

• intracellular aggregates containing amyloid oligomer are seen in hearts of 6 month old mice

growth/size/body

cardiac hypertrophy ( J:197853 )

• mice exhibit cardiac hypertrophy, with increased heart weight/body weight ratios at 6 months of age