Phenotypes Associated with This Genotype

Genotype
MGI:6331111

• Allelic Composition: P2rx7^{tm1.1(P2RX7)Jde}/P2rx7^{tm2.1(P2RX7*)Jde}
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:251657 )

N • no differences in emotional behavior are seen in the open field test, elevated plus maze, dark-light box test or forced swim test

N • mice subjected to chronic social defeat stress for 3 weeks show similar physiological and neuroendocrine changes as control mice

abnormal sleep behavior ( J:251657 )

• mice exhibit altered sleep and attenuated quality of sleep

abnormal non-rapid eye movement sleep pattern ( J:251657 )

• only a small amount of deep non-REM sleep is detected in mice, suggesting a shallower non-REM sleep stage

abnormal slow-wave sleep pattern ( J:251657 )

• slow-wave activity during non-REM sleep, measuring the depth of non-REM sleep, is lower

increased frequency of paradoxical sleep ( J:251657 )

• mice show a higher number of episode entries to REM sleep during the light period, suggesting a stronger drive toward REM sleep and more fragmented sleep cycles

fragmentation of sleep/wake states ( J:251657 )

• mice show a higher number of episode entries to REM sleep during the light period, suggesting a stronger drive toward REM sleep and more fragmented sleep cycles

cellular

abnormal cell physiology ( J:251657 )

• mixed primary hippocampal cells show attenuated calcium uptake in response to BzATP stimulation