Phenotypes for Olig2 Shh MGI:6357927 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Olig2^tm1(cre)Tmj/Olig2⁺ Shh^tm2Amc/Shh^tm2Amc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2^tm1(cre)Tmj mutation (0 available); any Olig2 mutation (46 available)
Shh^tm2Amc mutation (1 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:277700 )

N	• normal medial motor column (MMC) and hypaxial motor column (HMC) development at age E12.5 • normal proliferation of neural stem cells and overall spinal cord dorsal-ventral patterning at age E12.5

decreased motor neuron number ( J:277700 )

• at age E12.5

abnormal spinal cord lateral motor column morphology ( J:277700 )

• ~30% decrease in LMCm (medial) and LMCl (lateral) neurons at age E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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